Your first dose will always be RITUXAN® (rituximab) with the chemotherapy medicines fludarabine and cyclophosphamide. If you were able to receive and tolerate at least one full dose of RITUXAN, you may receive RITUXAN HYCELA® (rituximab/hyaluronidase human) with fludarabine and cyclophosphamide chemotherapy during future cycles of treatment. These drugs work together in different ways to fight cancer. The goal in using this combination of drugs is to keep your cancer from getting worse.
You will have 6 cycles, or rounds, of treatment. Each cycle will last 28 days. Treatment occurs on the first day of each cycle and is followed with time for rest and recovery.
RITUXAN HYCELA® (rituximab/hyaluronidase human) is a prescription medicine used to treat adults with:
You can only receive RITUXAN HYCELA after you receive at least 1 full dose of intravenous (IV) RITUXAN® (rituximab). Read the IV RITUXAN Medication Guide for more information about severe infusion reactions, which usually happen during the first dose with IV RITUXAN
RITUXAN HYCELA is not for use to treat medical conditions other than cancers
It is not known if RITUXAN HYCELA is safe and effective in children
RITUXAN HYCELA can cause serious side effects that can lead to death, including:
Skin reactions at or near the injection site (local), including injection site reactions can happen with RITUXAN HYCELA. Symptoms at or near the injection site may include: pain, swelling, hardness, redness, bleeding, itching, and rash. These reactions sometimes happen more than 24 hours after an injection of RITUXAN HYCELA
Tell your healthcare provider or get medical help right away if you get any of these symptoms during or after an injection of RITUXAN HYCELA: hives (red itchy welts) or rash; itching; swelling of your lips, tongue, throat, or face; sudden cough; shortness of breath, difficulty breathing, or wheezing; weakness; dizziness or feeling faint; palpitations (feeling like your heart is racing or fluttering); chest pain; fever; chills or shaking chills
RITUXAN HYCELA can cause serious side effects, including:
Your healthcare provider will stop treatment with RITUXAN HYCELA if you have severe, serious, or life-threatening side effects.
The most common side effects of RITUXAN HYCELA in people with:
Before receiving RITUXAN HYCELA, tell your healthcare provider about all of your medical conditions, including if you:
These are not all of the possible side effects with RITUXAN HYCELA. Call your doctor for medical advice about side effects. Please see the full Prescribing Information, including BOXED WARNINGS and Medication Guide, for additional Important Safety Information.
You may report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at (888) 835-2555.
The BrandX™ Co-pay Card Program may help lower the out-of-pocket costs for your patients.
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