Your first dose will always be RITUXAN® (rituximab) with the chemotherapy medicines fludarabine and cyclophosphamide. If you were able to receive and tolerate at least one full dose of RITUXAN, you may receive RITUXAN HYCELA™ (rituximab/hyaluronidase human) with fludarabine and cyclophosphamide chemotherapy during future cycles of treatment. These drugs work together in different ways to fight cancer. The goal in using this combination of drugs is to keep your cancer from getting worse.

You will have 6 cycles, or rounds, of treatment. Each cycle will last 28 days. Treatment occurs on the first day of each cycle and is followed with time for rest and recovery.